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Series B investors active this year

224 US Series B investors filed a new fund, deal vehicle or board seat with the SEC in the last 12 months, 86 (38%) of them in the last 90 days. The top home states are California (98), New York (40) and Massachusetts (22); the most common sectors are AI & ML (88), Healthcare (48) and B2B Software (48). For the 194 with a stated or estimated check size, the median range is $2.5M–$7.6M. Stage comes from the investor's own website where it says; otherwise from fund size and the rounds it has joined, with angels, syndicates and accelerators counted as pre-seed and seed.

Updated from SEC filings · How we build this list

Who are the most active Series B investors?

By new SEC filings in the last 12 months, the most active are AVSF, HCM, Lightspeed, Astro and Thrive Capital Partners.

How many Series B investors are investing right now?

224 filed a new fund, deal vehicle or board seat with the SEC in the last 12 months, 86 of them in the last 90 days.

How much do Series B investors typically invest?

The median estimated check is $2.5M–$7.6M, across 194 investors with a plausible estimate. Actual checks vary by round and lead role.

Where are Series B investors based?

Most are in California (98), New York (40) and Massachusetts (22).

What sectors do Series B investors back most?

AI & ML (88), Healthcare (48) and B2B Software (48) lead, by investors with recent activity in each.

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  • AVSFVC firm · Manchester, NH

    Pre-seed to Growth · checks $25K–$100K (est.)

    AI & MLHealthcareSpaceBiotech & Pharma+1
  • HCMVC firm · San Francisco, CA

    Seed to Series B · checks $4.2M–$12.6M (est.)

    Sector focus not yet verified
  • LightspeedVC firm · Menlo Park, CA

    Seed to Growth

    CybersecurityAI & ML
  • AstroSyndicate · New York, NY

    Pre-seed to Growth

    SpaceAI & ML
  • Thrive Capital PartnersVC firm · New York, NY

    Seed to Growth

    Sector focus not yet verified
  • AltraSyndicate · New York, NY

    Series B, Growth

    AI & MLB2B SoftwareFintech
  • Sequoia CapitalVC firm · Menlo Park, CA

    Seed to Growth

    AI & ML
  • DeviationVC firm · New York, NY

    Seed to Series B

    Biotech & PharmaHardware & RoboticsAI & MLHealthcare
  • Nea CHVC firm · Menlo Park, CA

    Seed to Growth

    Biotech & PharmaB2B SoftwareAI & MLConsumer+1
  • AccelVC firm · Palo Alto, CA

    Seed to Growth

    B2B SoftwareHealthcare
  • Tandem VenturesVC firm · Lehi, UT

    Pre-seed to Series B · checks $500K–$1M (est.)

    Media, Gaming & CreatorFintech
  • Spark CapitalVC firm · Boston, MA

    Seed to Growth

    AI & ML
  • Caffeinated CapitalVC firm · Aspen, CO

    Seed to Growth · checks $150K–$450K (est.)

    B2B SoftwareHealthcareIndustrial & ManufacturingFintech
  • Andreessen HorowitzVC firm · Menlo Park, CA

    Seed to Growth

    AI & MLDeveloper Tools
  • BenchmarkVC firm · Gig Harbor, WA

    Series A to Growth · checks $7.5M–$22.5M (est.)

    Deep TechAI & MLDeveloper Tools
  • Denver AngelsSyndicate · Denver, CO

    Pre-seed to Series B · checks $250K–$3M (est.)

    ConsumerReal Estate & PropTechHealthcareB2B Software+1
  • CostanoaVC firm · Palo Alto, CA

    Seed to Series B · checks $500K–$1.5M (est.)

    B2B Software
  • Garuda VenturesSyndicate · Orinda, CA

    Seed, Series B · checks $500K–$1.5M (est.)

    Hardware & RoboticsAI & MLIndustrial & Manufacturing
  • Bessemer VentureVC firm · Larchmont, NY

    Seed to Growth

    B2B SoftwareCybersecurity
  • LiquidVC firm · San Francisco, CA

    Pre-seed to Growth · checks $250K–$500K (est.)

    Sector focus not yet verified
  • Silverton PartnersVC firm · Austin, TX

    Seed to Series B · checks $250K–$750K (est.)

    HealthcareAI & MLCybersecurity
  • Khosla VenturesVC firm · Menlo Park, CA

    Seed to Growth

    AI & MLHealthcareClimate & Energy
  • USVVC firm · New York, NY

    Seed to Series B · checks $4M–$12M (est.)

    Climate & EnergyB2B Software
  • EngineVC firm · Cambridge, MA

    Seed to Series B · checks $5M–$15M (est.)

    Climate & EnergyAI & MLIndustrial & ManufacturingSpace
  • GreycroftVC firm · New York, NY

    Seed to Series B · checks $6M–$18M (est.)

    ConsumerClimate & EnergyAI & ML
  • Kleiner PerkinsVC firm · Menlo Park, CA

    Seed to Growth

    Biotech & PharmaDefense & Aerospace
  • Redpoint OmegaVC firm · Woodside, CA

    Seed to Series B · checks $2M–$6M (est.)

    Insurtech
  • BOC VenturesVC firm · New York, NY

    Seed to Series B · checks $2M–$6M (est.)

    AI & ML
  • Vida VenturesVC firm · Los Angeles, CA

    Series A to Growth · checks $5M–$15M (est.)

    Biotech & Pharma
  • Lux VenturesVC firm · New York, NY

    Seed to Growth · checks $4.28M–$34.6M (est.)

    AI & MLB2B SoftwareMedia, Gaming & CreatorDefense & Aerospace
  • ARCH VentureVC firm · Chicago, IL

    Seed to Growth · checks $4.05M–$92.5M (est.)

    Biotech & PharmaHealthcare
  • UpfrontVC firm · Los Angeles, CA

    Pre-seed to Series B · checks $100K–$300K (est.)

    B2B SoftwareHealthcare
  • CongruentVC firm · San Francisco, CA

    Seed to Series B · checks $850K–$2.55M (est.)

    Hardware & RoboticsClimate & EnergyDeep Tech
  • G2VPVC firm · Portola Valley, CA

    Series B, Growth · checks $525K–$1.6M (est.)

    Climate & EnergyAI & MLDeveloper Tools
  • Infinite CapitalSyndicate · West Palm Beach, FL

    Seed to Growth · checks $25M–$50M (est.)

    AI & MLDefense & AerospaceClimate & EnergyCrypto & Web3
  • First Round CapitalVC firm · Philadelphia, PA

    Seed to Series B · checks $3.25M–$9.75M (est.)

    HealthcareAI & MLB2B SoftwareFood & Agriculture
  • AmplifyVC firm · Menlo Park, CA

    Seed to Growth · checks $3M–$9M (est.)

    Biotech & PharmaDeep Tech
  • Technology ImpactVC firm · Palo Alto, CA

    Series A to Growth · checks $7M–$21M (est.)

    Climate & EnergyDeep TechIndustrial & Manufacturing
  • Mana VenturesVC firm · Seattle, WA

    Seed to Growth

    AI & MLSpaceHardware & Robotics
  • MC LongevityVC firm · New York, NY

    Seed to Growth · checks $5.08M–$15.3M (est.)

    Biotech & PharmaHealthcare