Venture capital firms in Pennsylvania
26 venture firms based in Pennsylvania filed a new fund, deal vehicle or board seat with the SEC in the last 12 months, 7 (27%) of them in the last 90 days. The most common sectors are B2B Software (4), Healthcare (3) and AI & ML (2). For the 18 with a stated or estimated check size, the median range is $1M–$3M. Many invest nationally, so also check the full list of venture firms.
Updated from SEC filings · How we build this list
Who are the most active venture firms in Pennsylvania?
By new SEC filings in the last 12 months, the most active are First Round Capital, Usit, Proofpoint Capital, OVP and Valley Capital Partners.
How many venture firms in Pennsylvania are investing right now?
26 filed a new fund, deal vehicle or board seat with the SEC in the last 12 months, 7 of them in the last 90 days.
How much do venture firms in Pennsylvania typically invest?
The median estimated check is $1M–$3M, across 18 investors with a plausible estimate. Actual checks vary by round and lead role.
What sectors do venture firms in Pennsylvania back most?
B2B Software (4), Healthcare (3) and AI & ML (2) lead, by investors with recent activity in each.
Start a 3-day trial to rank these 26 investors by fit with your startup and see contacts and warm paths.
Rank them for me- Active Aug 2026
First Round CapitalVC firm · Philadelphia, PA
Seed to Series B · checks $3.25M–$9.75M (est.)
HealthcareAI & MLB2B SoftwareFood & Agriculture - Active Aug 2026
- Active Jun 2026
Proofpoint CapitalVC firm · Phoenixville, PA
Seed, Series A · checks $2M–$6M (est.)
AI & MLBiotech & PharmaB2B Software - Active Apr 2026
- Active Mar 2026
Valley Capital PartnersVC firm · Pittsburg, PA
Seed, Series A · checks $1M–$3M (est.)
Sector focus not yet verified - Active Sep 2026
Verdis Seed Venture CapitalVC firm · West Conshohocken, PA
Seed, Series A · checks $1.5M–$4.5M (est.)
Sector focus not yet verified - Active Sep 2026
- Active Sep 2026
MissionOGVC firm · Philadelphia, PA
Series A · checks $5M–$10M (est.)
FintechB2B SoftwareCybersecurity - Active Aug 2026
NeXeption CapitalVC firm · Chester Springs, PA
Pre-seed, Seed · checks $250K–$750K (est.)
Biotech & PharmaHealthcare - Active Aug 2026
- Active Jul 2026
Alpha Ascent KaikakuVC firm · Philadelphia, PA
Pre-seed, Seed · checks $50K–$100K (est.)
Sector focus not yet verified - Active Jun 2026
- Active Jun 2026
North Haven Venture CapitalVC firm · West Conshohocken, PA
Seed to Series B · checks $2.45M–$7.35M (est.)
Sector focus not yet verified - Active Apr 2026
Verdict CapitalVC firm · Gladwyne, PA
Seed to Series B · checks $3M–$9M (est.)
Sector focus not yet verified - Active Apr 2026
Keystone InnovationVC firm · York, PA
Pre-seed, Seed · checks $150K–$450K (est.)
Industrial & Manufacturing - Active Mar 2026
Alpha Ascent OxyopiaVC firm · Philadelphia, PA
Pre-seed, Seed · checks $100K–$250K (est.)
Sector focus not yet verified - Active Mar 2026
Bay Park VenturesVC firm · Philadelphia, PA
Pre-seed, Seed · checks $100K–$300K (est.)
Sector focus not yet verified - Active Mar 2026
- Active Feb 2026
- Active Feb 2026
- Active Jan 2026
- Active Dec 2025
Lulu Cheng MeserveyVC firm · Philadelphia, PA
Pre-seed, Seed · checks $400K–$1.2M (est.)
Media, Gaming & Creator - Active Nov 2025
- Active Nov 2025
Alpha Ascent CogentVC firm · Philadelphia, PA
Pre-seed, Seed · checks $175K–$550K (est.)
Sector focus not yet verified - Active Oct 2025
V360 Holdings LLC Series Darrery Capital TolkenVC firm · Pittsburgh, PA
Seed, Series A
Sector focus not yet verified - Active Oct 2025