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Venture capital firms in Massachusetts

119 venture firms based in Massachusetts filed a new fund, deal vehicle or board seat with the SEC in the last 12 months, 33 (28%) of them in the last 90 days. The most common sectors are Healthcare (18), AI & ML (14) and Biotech & Pharma (13). For the 69 with a stated or estimated check size, the median range is $1M–$3M. Many invest nationally, so also check the full list of venture firms.

Updated from SEC filings · How we build this list

Who are the most active venture firms in Massachusetts?

By new SEC filings in the last 12 months, the most active are GC Venture, Spark Capital, Averin, J2 Ventures Strategic and Engine.

How many venture firms in Massachusetts are investing right now?

119 filed a new fund, deal vehicle or board seat with the SEC in the last 12 months, 33 of them in the last 90 days.

How much do venture firms in Massachusetts typically invest?

The median estimated check is $1M–$3M, across 69 investors with a plausible estimate. Actual checks vary by round and lead role.

What sectors do venture firms in Massachusetts back most?

Healthcare (18), AI & ML (14) and Biotech & Pharma (13) lead, by investors with recent activity in each.

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  • GC VentureVC firm · Cambridge, MA

    Seed, Series A · checks $800K–$2.45M (est.)

    Sector focus not yet verified

  • Spark CapitalVC firm · Boston, MA

    Seed to Growth

    AI & ML

  • AverinVC firm · Andover, MA

    Seed · checks $3.5M–$10.5M (est.)

    HealthcareAI & ML

  • J2 Ventures StrategicVC firm · Boston, MA

    Seed, Series A · checks $125K–$350K (est.)

    AI & MLDeveloper ToolsCybersecurityGovTech & Public Sector

  • EngineVC firm · Cambridge, MA

    Seed to Series B · checks $5M–$15M (est.)

    Climate & EnergyAI & MLIndustrial & ManufacturingSpace

  • Azolla VenturesVC firm · Cambridge, MA

    Seed, Series A · checks $1.5M–$4.5M (est.)

    Climate & EnergyB2B Software

  • AV FoundationVC firm · Boston, MA

    Seed, Series A

    Sector focus not yet verified

  • Polaris PartnersVC firm · Boston, MA

    Seed to Growth · checks $5M–$15M (est.)

    Biotech & PharmaHealthcareMedia, Gaming & CreatorFintech+1

  • Third Rock VenturesVC firm · Boston, MA

    Series A to Growth · checks $7.5M–$22.5M (est.)

    Biotech & PharmaHealthcare

  • AltimeterVC firm · Boston, MA

    Seed, Series A · checks $1M–$3M (est.)

    Sector focus not yet verified

  • HLM VMVC firm · Waltham, MA

    Seed, Series A · checks $625K–$1.85M (est.)

    Healthcare

  • Atlas VentureVC firm · Boston, MA

    Series B, Growth · checks $4M–$12M (est.)

    Biotech & Pharma

  • Transformation CapitalVC firm · Boston, MA

    Pre-seed, Series B · checks $150K–$450K (est.)

    HealthcareClimate & Energy

  • FH Venture PartnersVC firm · Boston, MA

    Seed, Series A

    Biotech & Pharma

  • Safar PartnersVC firm · Cambridge, MA

    Seed to Series B · checks $3M–$9M (est.)

    HealthcareAI & MLIndustrial & ManufacturingClimate & Energy

  • 021T CapitalVC firm · Cambridge, MA

    Seed, Series A · checks $1M–$3M (est.)

    Sector focus not yet verified

  • Breakthrough Energy VenturesVC firm · Boston, MA

    Seed, Series A · checks $1M–$3M (est.)

    Climate & Energy

  • Elephant PartnersVC firm · Boston, MA

    Series A to Growth · checks $7M–$21M (est.)

    B2B SoftwareE-commerce & RetailConsumer

  • Branch Venture PartnersVC firm · Boston, MA

    Seed, Series A

    Sector focus not yet verified

  • Altimeter KilaueaVC firm · Boston, MA

    Pre-seed, Seed · checks $400K–$1.2M (est.)

    Sector focus not yet verified

  • CafeVC firm · Boston, MA

    Pre-seed, Seed · checks $400K–$1.2M (est.)

    Sector focus not yet verified

  • LoLa CapitalVC firm · Prides Crossing, MA

    Seed, Series A

    Sector focus not yet verified

  • Indicator VenturesVC firm · Wellesley, MA

    Seed · checks $725K–$2.15M (est.)

    FintechHealthcareE-commerce & Retail

  • Skeleton Key SciTechVC firm · Boston, MA

    Pre-seed, Seed · checks $75K–$250K (est.)

    Sector focus not yet verified

  • Altimeter Premier GrowthVC firm · Boston, MA

    Series B, Growth · checks $15.6M–$46.6M (est.)

    Sector focus not yet verified

  • RaptorVC firm · Boston, MA

    Pre-seed, Seed · checks $50K–$150K (est.)

    ConsumerDeep TechReal Estate & PropTechMedia, Gaming & Creator

  • Ot HealthcareVC firm · Boston, MA

    Pre-seed, Seed · checks $25K–$100K (est.)

    Healthcare

  • 2026 FAN PierVC firm · Boston, MA

    Seed, Series A

    Sector focus not yet verified

  • Milemark AptaminoVC firm · Cambridge, MA

    Seed, Series A

    Sector focus not yet verified

  • Fidelity VentureVC firm · Boston, MA

    Pre-seed, Seed · checks $250K–$750K (est.)

    Sector focus not yet verified

  • LRVHealthVC firm · Boston, MA

    Seed to Series B · checks $2M–$6M (est.)

    Healthcare

  • Castle Island VenturesVC firm · Boston, MA

    Seed, Series A · checks $1.68M–$5.05M (est.)

    FintechB2B SoftwareHealthcare

  • U.S. Boston Growth Capital QSBSVC firm · Lincoln, MA

    Seed, Series A

    Healthcare

  • GC Venture XIII ArrangerVC firm · Cambridge, MA

    Seed, Series A

    Sector focus not yet verified

  • Altimeter CatskillVC firm · Boston, MA

    Pre-seed, Seed · checks $250K–$750K (est.)

    Sector focus not yet verified

  • AV HealthtechVC firm · Boston, MA

    Seed, Series A

    Sector focus not yet verified

  • Alaris VenturesVC firm · Boston, MA

    Seed, Series A

    Sector focus not yet verified

  • InflectionVC firm · Framingham, MA

    Pre-seed, Seed · checks $500K–$1.5M (est.)

    Sector focus not yet verified

  • Socratic PolarisVC firm · Boston, MA

    Pre-seed, Seed · checks $25K–$100K (est.)

    Sector focus not yet verified

  • Socratic PicojoolVC firm · Boston, MA

    Pre-seed, Seed · checks $150K–$450K (est.)

    Sector focus not yet verified