Column

VC firm · San Francisco, CA

Verified active in the last 12 monthsSEC-registered adviser

Venture firm based in San Francisco, CA. Most recent fund on file: Column Group Opportunity IV, LP ($600M offering), filed Dec 2025. Partners sit on the boards of 7 startups that raised recently.

“The Column Group (TCG) is a venture ecosystem dedicated to fueling scientific innovation in the life sciences industry.” (from the firm’s website)

Stages: Seed to Growth
Typical check (est.): $3.77M–$31.8M
Latest fund: $600M · Dec 2025
Last verified activity: Dec 2025

Focus

Biotech & Pharma

Recent portfolio activity

NGM Bio Holdings
Board seat · CA
Jul 2024
Site Tx
Board seat · CA
Apr 2024
Neurona Therapeutics
Board seat · CA
Feb 2024
Carmot Therapeutics
Board seat · CA
Jun 2023

Funds and vehicles on SEC file

Column Group Opportunity IV, LP
Fund · $600M offering
Dec 2025
Column Group VI, LP
Fund · $600M offering
Dec 2025
Column Group-Neuro II, LP
Fund · $100M offering
Feb 2024

Sources

SEC Form D: Column Group Opportunity IV, LPDec 16, 2025
SEC Form D: Column Group VI, LPDec 16, 2025
SEC Form D: Column Group-Neuro II, LPFeb 13, 2024
SEC adviser record: THE Column GroupMar 19, 2026
Firm websiteOct 12, 2026

Profile last verified Oct 12, 2026. Is this you? Correct or remove this profile.